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Medical images reveal the internal structure of human organs and provides information on how their shapes are affected by disease. Computational anatomy studies datasets of such shapes and applies statistical methods in shape spaces to infer new information on the diseases. The following provide some examples of such studies, in the context of brain, heart and lung disease.

Here are some references (more details will appear later on this page).

The Diffeomorphometry of Temporal Lobe Structures in Preclinical Alzheimer�s Disease, Michael I Miller, Laurent Younes, J Tilak Ratnanather, Timothy Brown, Huong Trinh, Elizabeth Postell, David S Lee, Mei-Cheng Wang, Susumu Mori, Richard O�Brien, Marilyn Albert, NeuroImage: Clinical, 2013
Regionally selective atrophy of subcortical structures in prodromal HD as revealed by statistical shape analysis, Laurent Younes, J Tilak Ratnanather, Timothy Brown, Elizabeth Aylward, Peg Nopoulos, Hans Johnson, Vincent A Magnotta, Jane S Paulsen, Russell L Margolis, Roger L Albin, Michael I Miller, Christopher A Ross, Human brain mapping, 2012
Matching sparse sets of cardiac image cross-sections using large deformation diffeomorphic metric mapping algorithm, Siamak Ardekani, Aastha Jain, Saurabh Jain, Theodore P Abraham, Maria R Abraham, Stefan Zimmerman, Raimond L Winslow, Michael I Miller, Laurent Younes, in Statistical Atlases and Computational Models of the Heart. Imaging and Modelling Challenges, 2012
Diffuse Abnormality of Low to Moderately Organized White Matter in Schizophrenia, Sarah AJ Reading, Kenichi Oishi, Graham W Redgrave, Julie McEntee, Megan Shanahan, Nadine Yoritomo, Laurent Younes, Susumu Mori, Michael I Miller, Peter van Zijl, Russell L Margolis, Christopher A Ross, Brain Connectivity 1 (6), 511-519, 2011
Incorporating user input in template-based segmentation, C Vidal, D Beggs, L Younes, SK Jain, B Jedynak, Biomedical Imaging: From Nano to Macro, 2011 IEEE International Symposium on, 2011
Multi-modal MRI analysis with disease-specific spatial filtering: initial testing to predict mild cognitive impairment patients who convert to Alzheimer�s disease, Kenichi Oishi, Kazi Akhter, Michelle Mielke, Can Ceritoglu, Jiangyang Zhang, Hangyi Jiang, Xin Li, Laurent Younes, Michael I Miller, Peter CM van Zijl, Marilyn Albert, Constantine G Lyketsos, Susumu Mori, Frontiers in neurology 2, 2011
Neuroanatomical asymmetry patterns in individuals with schizophrenia and their non-psychotic siblings, A Qiu, L Wang, L Younes, MP Harms, JT Ratnanather, MI Miller, JG Csernansky, Neuroimage 47 (4), 1221-1229, 2009
Cardiac motion analysis in ischemic and non-ischemic cardiomyopathy using parallel transport, S Ardekani, RG Weiss, AC Lardo, RT George, JAC Lima, KC Wu, MI Miller, RL ..., Biomedical Imaging: From Nano to Macro, 2009. ISBI'09. IEEE International Symposium on, 2009
Template registration with missing parts: Application to the segmentation of M. tuberculosis infected lungs, C Vidal, J Hewitt, S Davis, L Younes, S Jain, B Jedynak, Biomedical Imaging: From Nano to Macro, 2009. ISBI'09. IEEE International Symposium on, 2009
Computational method for identifying and quantifying shape features of human left ventricular remodeling, Siamak Ardekani, Robert G Weiss, Albert C Lardo, Richard T George, Joao AC Lima, Katherine C Wu, Michael I Miller, Raimond L Winslow, Laurent Younes, Annals of biomedical engineering 37 (6), 1043-1054, 2009
Time sequence diffeomorphic metric mapping and parallel transport track time-dependent shape changes, A Qiu, M Albert, L Younes, MI Miller, NeuroImage 45 (1), S51-S60, 2009
Landmark-referenced voxel-based analysis of diffusion tensor images of the brainstem white matter tracts: application in patients with middle cerebral artery stroke, Weihong Zhang, Xin Li, Jiangyang Zhang, Andreas Luft, Daniel F Hanley, Peter van Zijl, Michael I Miller, Laurent Younes, Susumu Mori, Neuroimage 44 (3), 906-913, 2009
Parallel transport in diffeomorphisms distinguishes the time-dependent pattern of hippocampal surface deformation due to healthy aging and the dementia of the Alzheimer's type, A Qiu, L Younes, MI Miller, JG Csernansky, NeuroImage 40 (1), 68-76, 2008
Quantitative cortical mapping of fractional anisotropy in developing rat brains, H Huang, A Yamamoto, MA Hossain, L Younes, S Mori, The Journal of Neuroscience 28 (6), 1427-1433, 2008
Combining anatomical manifold information via diffeomorphic metric mappings for studying cortical thinning of the cingulate gyrus in schizophrenia, Anqi Qiu, Laurent Younes, Lei Wang, J Tilak Ratnanather, Sarah K Gillepsie, Gillian Kaplan, John Csernansky, Michael I Miller, NeuroImage 37 (3), 821-833, 2007
Large deformation diffeomorphism and momentum based hippocampal shape discrimination in dementia of the Alzheimer type, Lei Wang, Faisal Beg, Tilak Ratnanather, Can Ceritoglu, Laurent Younes, John C Morris, John G Csernansky, Michael I Miller, Medical Imaging, IEEE Transactions on 26 (4), 462-470, 2007
Consistent realignment of 3D diffusion tensor MRI eigenvectors, MF Beg, R Dickie, G Golds, L Younes, Medical Imaging, 651242-651242-9, 2007
Evidence of structural remodeling in the dyssynchronous failing heart, Patrick A Helm, Laurent Younes, Mirza F Beg, Daniel B Ennis, Christophe Leclercq, Owen P Faris, Elliot McVeigh, David Kass, Michael I Miller, Raimond L Winslow, Circulation Research 98 (1), 125-132, 2006
Ex vivo 3D diffusion tensor imaging and quantification of cardiac laminar structure, PA Helm, HJ Tseng, L Younes, ER McVeigh, RL Winslow, Magnetic Resonance in Medicine 54 (4), 850-859, 2005