J. Tilak Ratnanather
Center for Imaging Science : About | Research | Publications | Education | Activities | Downloads | Visiting

J. Tilak Ratnanather

Assistant Research Professor

Center for Imaging Science

World Wide Web

Assistant Information

  • Pam Lauria
    Clark 301
    (410) 516-3826
    pam@cis.jhu.edu
  • Awards

    • National Partnership in Advanced Computational Infrastructure Diversity in Computing Travel Award. October 01, 2001 - October 31, 2001
    • NSF/University of California Program in Mathematics and Molecular Biology Postdoctoral Fellow October 01, 1994 - September 30, 1996
    • Royal Society of London - Australian Academy of Sciences Postdoctoral Fellow July 01, 1991 - July 31, 1991

    Education

    • D.Phil. MathematicsUniversity of Oxford, 1985 - 1989
    • B.Sc. MathematicsUniversity College London, 1982 - 1985

    Experience

    • Assistant Research Professor, Center for Imaging Science, Dept. of Biomedical Engineering, Johns Hopkins University, Baltimore, MD. February, 2002 - Present
    • Assistant Research Professor, Institute of Computational Medicine, Johns Hopkins University, Baltimore, MD. February, 2006 - Present
    • Staff Scientist, F.M. Kirby Functional Imaging Research Center, Kennedy Krieger Institute, Baltimore, MD. August, 2001 - Present
    • Visiting Scientist, Institute of Fundamental Science, Massey University, Palmerston North, New Zealand. 2005 - 2005
    • Research Associate, Center for Imaging Science, Depts of Electrical and Computer Engineering and Biomedical Engineering, Johns Hopkins University, Baltimore, MD. September, 1998 - February, 2002
    • Visiting Scientist, Dept. of Mathematics, City University, London. 1992 - 2001
    • Postdoctoral Fellow, Dept. of Biomedical Engineering, Johns Hopkins University, School of Medicine, Baltimore, MD. October, 1994 - August, 1998
    • Postdoctoral Fellow, Dept of Otolaryngology - Head & Neck Surgery, Johns Hopkins University, School of Medicine, Baltimore, MD. October, 1991 - September, 1994
    • Postdoctoral Fellow, Dept. of Mathematics, City University, London. October, 1989 - September, 1991
    • Visiting Scientist, Dept. of Mechanical Engineering, University of Sydney, Australia. July, 1991
    • Visiting Scientist, Dept. of Mechanical Engineering, Clarkson University, Potsdam, NY. August, 1990

    Grants and Contracts

    • Morphometry of the Superior Temporal Gyrus, NIMH/NIH  Status: Awarded/Active January 01, 2004 - December 31, 2007
    • Computational Anatomy of the deafened auditory cortex, National Organization for Hearing Research $15,000 Status: Awarded/Active January 01, 2004 - December 31, 2005
    • Adult Children Study – Neuroanatomical Biomarkers, National Institute of Aging, NIH  Status: Awarded/Active September, 2005 - Present
    • Focused Research Group: The geometry, mechanics and statistics of the infinite-dimensional manifold of shapes, Division of Mathematical Sciences, NSF   Status: Awarded/Active July, 2005 - June, 2008
    • Assessment of the Right Hemisphere Auditory Speech Function, National Institute of Deafness and Other Communication Disorders, NIH  Status: Awarded/Active April, 2005 - March, 2007
    • National Center for Research Resource (NCRR) for Quantitative Functional MRI at 1.5 Tesla: Technical and Research Development (TRD) Program - Algorithmic Methods for Anatomical Brain Analysis, F.M. Kirby Functional Imaging Center, Kennedy-Krieger Institute, Baltimore, MD  Status: Awarded/Active July, 2001 - June, 2007
    • High Dimensional Brain Mapping Core, Conte Center for Neuroscience Research, Washington University St Louis  Status: Awarded/Active September, 2001 - July, 2009
    • Healthy Aging and Senile Dementia Program Project – Preclinical Diagnosis of Alzheimer’s Disease by High Dimensional Brain Mapping, Washington University St Louis  Status: Awarded/Terminated October, 2001 - December, 2003

    Professional Activities

    • Completed “Introduction to Metric Pattern Theory” web course
    • ZRG1 MDCN-G (55) Human Brain Project Study Section, National Institutes of Health (9/04)
    • Guest co-editor NeuroImage Special Issue “Mathematics in Brain Imaging”. Vol 23. Supplement 1. September 2004.
    • “Computational Anatomy: New Frontiers in Biomedical Imaging” Session co-chair, 2005 Annual Fall Meeting, Biomedical Engineering Society, Baltimore, MD (9/05)
    • Ad-Hoc Committee for Patients Advocacy Group Relations, Association for Research in Otolaryngology. (6/06/03; 3/05-)
    • College Financial Aid Award Committee, Alexander Graham Bell Association for the Deaf, Washington, DC. (7/96-)
    • Program Committee, 1998 Alexander Graham Bell Association for the Deaf International Convention, Little Rock, AR
    • Federal Communications Commission Hearing Aid Compatible Telephone Act Negotiated Rulemaking Committee, Washington, DC. (5/95)
    • Reviewer: The Volta Review; Quarterly Journal of Mechanics and Applied Mathematics; Journal of Women and Minorities in Science and Engineering; NeuroImage; IEEE Trans. in Biomedical Engineering; Journal of Mathematical Imaging and Vision; SIAM J. Sci. Comp.; Louisiana State University: external review of NSF pre-proposal; MICCAI; IEEE Trans on Image Processing; Annals of Biomedical Engineering
    • Organizations: Association for Research in Otolaryngology; Society for Industrial and Applied Mathematics (including Life Sciences and Imaging Sciences Groups); American Mathematical Society; Biomedical Engineering Society; Alexander Graham Bell Association for the Deaf and Hard of Hearing
    • Program Committee, Frontiers in the Convergence of Bioscience and Information Technology, Korea, 2007.
    • Program Committee, Summer 2007 Program on the Geometry and Statistics of Shape Spaces, SAMSI, Raleigh, NC, 2007

    Presentations

    • Applications of the Alternating Kernel Mixture model in Computational Anatomy Graduate School of Biomedical Engineering, University of New South Wales, Sydney, Australia. September 27, 2007. (Invited)
    • Neuro-imaging of the Deafened Auditory Cortex: potential applications and challenges Developing a Listening Ear. Newbury, England. July 09, 2007. (Invited)
    • A few unresolved, if not peripheral, questions on the auditory periphery from the periphery! The Auditory System. Mathematical Biosciences Institute, Ohio State University . June 27, 2007. (Invited)
    • Computational Auditory Phrenology: scratching the surface Mary Hare Grammar School for the Deaf, Newbury, England . June, 2006. (Invited)
    • Computational Auditory Phrenology: scratching the surface  Workshop on functional organization of the laminar structure of the auditory cortex . Johns Hopkins University. February 04, 2006. Workshop Organizer (Invited)
    • Computational Anatomy: New Frontiers in Biomedical Imaging 2005 Annual Fall Meeting, Biomedical Engineering Society. Baltimore, MD. September, 2005. Session co-chair (Invited)
    • Computational Anatomy of the deafened auditory cortex: implications for auditory rehabilitation Division of Audiology, School of Population Health, University of Auckland, New Zealand. August, 2005. (Invited)
    • Computational Anatomy: shape analysis of brain, cortical, cardiac and dendritic structures New Zealand Institute of Fundamental Sciences, Massey University (8/05).. August, 2005. (Invited)
    • “Salicylate effect on the hydraulic conductivity of the cochlear outer hair cell wall”,   Auditory Physiology Group, University of Auckland, New Zealand. August, 2005. (Invited)
    • Cortical cartography of the planum temporale in the auditory cortex  Neuropsychiatry Group, Prince of Wales Medical Research Institute, University of New South Wales. August, 2005. (Invited)
    • J. Tilak Ratnanather: Dynamic Programming Applications in Defining Cortical Manifold Boundaries Graduate Summer School “Mathematics in Brain Imaging”.  Institute of Pure and Applied Mathematics, UCLA, Los Angeles. July, 2004. (Invited)
    • J. Tilak Ratnanather: Computational Anatomy of the Auditory Cortex: implications for auditory rehabilitation 4th Research Symposium for Non-Scientists at the International Convention of the Alexander Graham Bell Association for the Deaf and Hard of Hearing. Anaheim, CA. June, 2004. (Invited)
    • Computational Anatomy: implications for auditory rehabilitation Bionic Ear Institute, University of Melbourne, Australia. October, 2003. (Invited)
    • Computational Anatomy: implications for auditory rehabilitation Cochlea Interest Group, University of New South Wales, Sydney, Australia. October, 2003. (Invited)
    • Computing Metric Distances Between Shapes and the Euler-Poincaré Equations of Computational Anatomy Image Analysis and Understanding Data from Scientific Experiments workshop. Los Alamos National Laboratory, Los Alamos, NM. December, 2002. Short Course (Invited)
    • Mini-Symposium on "Biomedical Image Analysis and Registration" 50th SIAM Annual Meeting. Philadelphia, PA. July, 2002. Co-chair (Invited)
    • Computing Geodesics Between Anatomical Images 1st SIAM Conference on Imaging Sciences. Boston, MA. March, 2002. Mini-Symposium on "Comparative Mathematical Structures in 3D Medical Image Analysis" (Invited)
    • Beyond the auditory cortex: possible applications of computational anatomy Cochlear Biophysics Laboratory, Bobby R. Alford Dept. of Otorhinolaryngology, Baylor College of Medicine, Houston, TX. October, 2001. (Invited)
    • Mentoring Women and Minorities National Partnership in Advanced Computational Infrastructure, All Hands Meeting. San Diego Supercomputer Center. February, 2000. Panelist (Invited)
    • The Ear-Works: the cellular basis of hearing Colloquium. California State University Northridge. January, 1999. (Invited)
    • Shake, rattle and roll: the mathematical biology of hearing Dept. of Mathematics, California State University Northridge. January, 1999. (Invited)
    • Dancing cochlear outer hair cells: the mathematical biology of hearing Dept. of Mathematics, Howard University. April, 1998. (Invited)
    • "Hear and Now" symposium  Midwinter Meeting of the Association for Research in Otolaryngology. St. Petersburg, FL. February, 1997. Panelist (Invited)
    • What they didn't teach us at school? - Fire in the belly Oxford Brookes University School of Education, Oxford, England. August, 1996. (Invited)
    • Is the outer hair cell wall viscoelastic Program in Mathematics and Molecular Biology retreat. Napa, CA. May, 1996. (Invited)
    • Water permeability and membrane-cytoskeleton-subsurface cisterna association in the cochlear outer hair cell Program in Mathematics and Molecular Biology retreat. Napa, CA. January, 1995. (Invited)
    • Making the most of the Sun workstation Dept. of Mathematics, City University London. October, 1991. (Invited)
    • On self induced thermal boundary layer separation Dept. of Mathematics, University of New South Wales, Sydney, Australia. February, 1991. (Invited)
    • Asymptotic modeling of turbulent and thermal boundary layers Dept. of Mechanical Engineering, Johns Hopkins University, Baltimore, MD. February, 1991. (Invited)
    • Numerical analysis of turbulent flows Dept. of Mathematics, City University London. February, 1990. (Invited)
    • Numerical analysis of turbulent flows Dept. of Mathematics, University College London. January, 1990. (Invited)

    Research Interests

    • Mathematical models in image analysis of the brain specifically hippocampus, cingulate gyrus, planum temporale, superior temporal gyrus, auditory cortex and medial prefrontal cortex which have been implicated in a variety of neuropsychiatric and neurodevelopmental disorders as schizophrenia, Alzheimer’s, epilepsy, major depression, speech and language processing.
    • Mathematical models of physiological fluid mechanics phenomena such as cochlear fluid mechanics and micromechanics of cochlear outer hair cell.
    • Computational and analytical methods for solving nonlinear partial differential equations arising in fluid mechanics and biology (e.g. boundary layer separation and EPDiff).
    • Online webcourses in applied mathematics.

    Publications: Abstracts

    1. Harms, M.P., Calabrese, D.R., Wang, L., Ratnanather, J., Miller, M.I., Csernansky, J. G. . "Abnormalities of cingulate gyrus neuroanatomy in siblings at risk for schizophrenia". Society for Neuroscience Annual Meeting, San Diego (2007)
    2. Ceritoglu, C., Wang, L., Malhotra, N., Ratnanather, J.T., Selemon, L.D., Csernansky, J.G., Miller, M.I. . "Delineation of a cytoarchitectonically defined macaque cortical area (46) in MRI via large deformation diffeomorphic metric mapping". Society for Neuroscience Annual Meeting, San Diego (2007)
    3. Rukhin, A., Vaillant, M., Qiu, A., Younes, L., Ratnanather, J.T. . "Analysis of hippocampal shape change over time in a study of Alzheimer’s Disease based on momenta of the EPDiff equation of Computational Anatomy". Effective Computational Methods for Highly Oscillatory Problems: The Interplay between Mathematical Theory and Applications, Isaac Newton Institute of Mathematical Sciences, Cambridge, UK (2007)
    4. Arrate, F., Younes, L., Ratnanather, J.T. . "A numerical method for solving the EPDiff equation of Computational Anatomy. ". Effective Computational Methods for Highly Oscillatory Problems: The Interplay between Mathematical Theory and Applications, Isaac Newton Institute of Mathematical Sciences, Cambridge, UK (2007)
    5. Arrate, F., Younes, L., Ratnanather, J.T.. "A numerical method for solving the EPDiff equation of Computational Anatomy". Statistics of Shape Spaces, SAMSI, Rayleigh, NC (2007)
    6. Lee, N.A., Mostofsky, S., Ratnanather, J.T.. "Automated Cortical Analysis of Planum Temporales in Children with Autism". Human Brain Mapping, Chicago (2007)
    7. Lee, N., Penumetcha, N., Priebe, C., Wang, L., Csernansky, J., Miller, M., Ratnanather, J. T. . "Alternating Kernel Mixture Segmentation of Hippocampus and Prefrontal Cortex: a validation study". Human Brain Mapping, Chicago (2007)
    8. Botteron, K.N, Babb, C.M., Nishino, T., Lobos, E., Todorov, A., Ratnanather, J.T., Miller, M.I., Chorbov, V., Todd, R.D.. "Lifetime trauma exposure, early onset MDD and 5-HTTLPR genotype influence on hipppocampal volume in a young female twin sample". Human Brain Mapping, Chicago (2007)
    9. Ratnanather, J.T., Younes, L., Zweck, J., Wang, L., Hosakere, M., Csernansky, J.G., Miller, M.I. . "Statistical Analysis of Surface Roughness via Local Area Maps: Application to the Cingulate in Healthy and Schizophrenic Subjects". International Congress on Schizophrenia Research, Colorado Springs, CO (2007)
    10. Pisano, D.V., Poynton, C.B., Honeycutt, N.A., Barta, P.E, Ratnanather, J.T. . "Delineating the superior temporal gyrus using dynamic programming in schizophrenia and bipolar disorder". International Congress on Schizophrenia Research, Colorado Springs, CO (2007)
    11. Qiu, A., Younes, L., Wang, L., Ratnanather, J.T., Csernansky, J.G., Miller, M.I. . "Cortical thinning of the cingulate gyrus in schizophrenia". International Congress on Schizophrenia Research, Colorado Springs, CO (2007)
    12. Pisano, D.V., Barta, P., Ratnanather, J.T.. "Morphometrics of the Superior Temporal Gyrus in the General Population". Midwinter Meeting of the Association for Research in Otolaryngology, Denver, CO (2007)
    13. Qiu, A., Barta, P., Miller, M.I., Ratnanather, J.T.. "Lateral asymmetry of the laminar structure of the planum temporale". Midwinter Meeting of the Association for Research in Otolaryngology (2006)
    14. Botteron, K.N., Babb,C.M., Nishino, T., Storch, E., Flake, L., Todd, R.D., Ratnanather, J.T., Miller, M.I.. "Hippocampus Volume in Twins with Early Onset Major Depression. ". Human Brain Mapping (2006)
    15. Ceyhan, E., Poynton, C., Qiu, A., Barta, P., Miller, M.I., Ratnanather, J.T.. "Statistical Analysis of Gender, Laterality and Diagnosis Effect on Planum Temporale". Human Brain Mapping (2006)
    16. Qiu, A., Vaillant, M., Barta, P., Miller, M.I., Ratnanather, J.T.. "Left planum temporale cortical thickness variation in schizophrenia". Human Brain Mapping (2006)
    17. Wang, L., Ceritoglu, C., Ratnanather, J.T., Beg, M.F., Morris, J.C., Csernansky, J.G., Miller, M.I. . "Initial Velocity and Large-Deformation Diffeomorphic Metric Mapping of Hippocampal Change in Dementia of Alzheimer Type (DAT)". Human Brain Mapping (2006)
    18. Aldridge, G.M., J.T. Ratnanather, M.E. Martone, M. Terada, M.F. Beg, L. Fong, E. Ceyhan, A.E. Kolasny, T.J.A. Brown, E.L. Cochran, S.J. Tang, D.V. Pisano, M. Vaillant, M.K. Hurdal, J.D. Churchill, W.T. Greenough, M.I. Miller, and M.H. Ellisman. "Semi-automated shape analysis of dendrite spines from animal models of FragileX and Parkinson's disease using Large Deformation Diffeomorphic Metric Mapping". Society for Neuroscience Annual Meeting (2005)
    19. Munn, M.A., J. Alexopoulos, T. Nishino, C.M. Babb, M. Hosakere, J.T. Ratnanather, R. Todd, M.I. Miller, and K.N. Botteron. "Amygdala volume analysis in twins with major depression". Human Brain Mapping (2005)
    20. Wang, L., M. Hosakere, E. Ceyhan, J.T. Ratnanather, G. Kaplan, M. Gado, J.G. Csernansky, and M.I. Miller. "Labeled Cortical Mantle Distance Mapping of the Cingulate Gyrus in Schizophrenia". Human Brain Mapping (2005)
    21. Beg, M.F., R.L. Buckner, B. Fischl, Y. Park, E. Ceyhan, C.E. Priebe, C. Ceritoglu, A.E. Kolasny, T. Brown, B. Quinn, P. Yu, B. Gold, J.T. Ratnanather, and M.I. Miller. "BIRN Brain Morphometry: Pattern classification of hippocampal shape analysis in a study of Alzheimer’s Disease". Human Brain Mapping (2005)
    22. Wang, L., M.F. Beg, J.T. Ratnanather, J.G. Csernansky, and M.I. Miller. "Validating Large-Deformation Diffeomorphic Metric Matching in Hippocampus". Human Brain Mapping (2005)
    23. Beg, M.F., J.T. Ratnanather, L. Wang, E. Ceyhan, C.E. Priebe, C. Ceritoglu, A. Khan, N. Lee, J.G. Csernansky, J.C. Morris, and M.I. Miller. "Metric distances between hippocampal shapes predict different rates of shape changes in dementia of Alzheimer type and nondemented subjects: a validation study". Human Brain Mapping (2005)
    24. Qiu, A., D. Bitouk, J.T. Ratnanather, C. Poynton, L. Wang, D. Boatman, P. Barta, J.G. Csernansky, and M.I. Miller. "Visualizing cortical thickness on the gray/white cortical surface". Human Brain Mapping (2005)
    25. Poynton, C., R. Lal, J.T. Ratnanather, S. Mori, D. Boatman, and M.I. Miller. "Probabilistic Tracking of Fiber Pathways Using Dynamic Programming. Human Brain Mapping". Human Brain Mapping (2005)
    26. Ceyhan, E., M. Hosakere, J. Alexopolous, T. Nishino, C. Babb, J.T. Ratnanather, R.D. Todd, K.N. Botteron, and M.I. Miller. "Analysis of Ventral Medial Prefrontal Cortex Metrics for Depression in Twins". Human Brain Mapping (2005)
    27. Qiu, A., D. Bitouk, J.T. Ratnanather, L. Wang, J.G. Csernansky, and M.I. Miller. "Cingulate Cortical Thickness Variability on the Gray/White Surface". International Congress on Schizophrenia Research, Savannah, GA (2005)
    28. Ratnanather, J.T. "The set of hearing-impaired mathematics PhDs is countably finite on the order of at least 22!!". Minorities in Mathematics Workshop, Institute for Mathematics and its Applications, University of Minnesota. (2005)
    29. Wang, L., J. Trein, M. Gado, M. Hosakere, J.T. Ratnanather, M.I. Miller, and J.G. Csernansky. "Volume, Surface Area, and Thickness of the Cingulate Gyrus in Schizophrenia Subjects". International Congress on Schizophrenia Research, Savannah, GA (2005)
    30. Ratnanather, J.T., C. Poynton, E. Ceyhan, A. Osdoit, and D. Boatman. "A cortical analysis of the laterality of the planum temporale in hearing, hearing-impaired and central auditory processing disorder subjects". Midwinter Meeting of the Association for Research in Otolaryngology (2005)
    31. Beg, M.F., C. Ceritoglu, A.E. Kolasny, C.E. Priebe, J.T. Ratnanather, R. Yashinski, L. Younes, P. Yu, J. Jovicich, R.L. Buckner, S. Pieper, B. Fischl, and M.I. Miller. "Biomedical Informatics Research Network: Multi-Site Processing Pipeline for Shape Analysis of Brain Structures". Human Brain Mapping (Abstracts) (2004) (Budapest, Hungary)
    32. Botteron, K.N., M. Hosakere, T. Nishino, C. Babb, J.T. Ratnanather, R.D. Todd, and M.I. Miller. "Ventral Medial Prefrontal Cortex Metrics in Early Onset Depression: A Twin MRI Study". Human Brain Mapping (Abstracts) (2004) (Budapest, Hungary)
    33. Botteron, K.N., Nishino, T., Hosakere, M., Babb, C.M., Alexopoulos, J., Flake, L., Ratnanather, J.T., Rogers, C., Heath, A.C., Todd, R.D., Miller, M.I. . "Ventral medial prefrontal cortex heritability and alternations in major depressive disorder: a twin MRI study. ". Abstracts for the XIIth World Congress of Psychiatric Genetics, Dublin, Ireland. (2004)
    34. Lee, N., J.T. Ratnanather, P.E. Barta, M.K. Hurdal, and M.I. Miller. "Dynamic Programming Definition of Boundaries of the Planum Temporale". Human Brain Mapping (2003) (New York City, NY)
    35. Hurdal, M.K., A. Lee, J.T. Ratnanather, T. Nishino, M.I. Miller, and K.N. Botteron. "Investigating the Medial Prefrontal Cortex with Cortical Flat Mappings". Human Brain Mapping (2003) (New York City, NY)
    36. Lee, N., J.T. Ratnanather, P.E. Barta, M.K. Hurdal, and M.I. Miller. "Dynamic Programming Definition of Boundaries of the Planum Temporale". Conformal Geometry of Surfaces: Theory, Computation and Application (2003) (University of Tennessee, Knoxville, TN)
    37. Ratnanather, J.T. "Dynamic Programming in Cortical Surface Analysis". Image Analysis and Understanding Data from Scientific Experiments Workshop (2002) (Los Alamos National Laboratory, Los Alamos, NM)
    38. Beg, M.F., J.T. Ratnanather, and M.I. Miller. "Computing geodesics between anatomical configurations". Diversity in Computing (2001) (Houston, TX)
    39. Beg, M.F., A. Majethia, M. Browne, T.H. Kaiser, M. Martone, K.F. Wong, A.B. Massie, J. Homer, J.T. Ratnanather, and M.I. Miller. "Enhancing tools to manipulate anatomical images: a step towards a federated neuroscience image database". National Partnership for Advanced Computational Infrastructure All-Hands Meeting (2001) (San Diego, CA)
    40. Ratnanather, J.T., S. Batman, H. Francis, J. Flores, P. Roberts, and R.C. Nutt. "Spatial analysis of spiral ganglion cells from human temporal bones". Midwinter Meeting of the Association for Research in Otolaryngology (2001)
    41. Flores, J., S. Batman, J.T. Ratnanather, and H. Francis. "A new method for analyzing 3-D trends in spiral ganglion cell density and distribution from a human temporal bone bank". Symposium on Synaptic Function in Hearing and Balance (2000) (Johns Hopkins University, Baltimore, MD)
    42. Stone, M., J.T. Ratnanather, C. Yang, and J. Yeh. "Ultrasound Imaging of Speech by Very Intelligible Profoundly Deaf Speakers". Alexander Graham Bell Association for the Deaf and Hard of Hearing International Convention (2000) (Philadelphia, PA)
    43. Beg, M. F., G. Bhanot, M.I. Miller, J.T. Ratnanather, R. Walkup, and L. Younes. "Computing Geodesics on Anatomies". National Partnership for Advanced Computational Infrastructure All-Hands Meeting (2000) (San Diego, CA)
    44. Beg, M.F., M.I. Miller, J.T. Ratnanather, and L. Younes. "A gradient method to solve a nonlinear optimization problem arising in computational anatomy". American Mathematical Society Annual Meeting (2000) (Washington, D.C.)
    45. Ratnanather, J.T., C. Jing., and M.I. Miller. "Computational Anatomy of the Brain". National Partnership for Advanced Computational Infrastructure All-Hands Meeting (1999) (San Diego Supercomputer Center)
    46. Ratnanather, J.T., A.A. Spector, A.S. Popel, and W.E. Brownell. "Analysis of viscoelastic deformations of the cochlear outer hair cell wall". Annual meeting of the American Mathematical Society (1998) (Baltimore, MD)
    47. Ratnanather, J.T., A.S. Popel, and W.E. Brownell. "A micro-fluidic analysis of the lateral wall of the cochlear outer hair cell". Michigan Interdisciplinary Mathematics Meeting on Modeling and Analysis in Medicine and Biology (1998) (Ann Arbor, MI)
    48. Ratnanather, J.T., A.A. Spector, A.S. Popel, and W.E. Brownell. "Viscosity effects on the dynamics of the cochlear outer hair cell". Annual Meeting of the Society of Mathematical Biology (1997) (Raleigh, NC)
    49. Ratnanather, J.T., A.A. Spector, A.S. Popel, and W.E. Brownell. "The fluid-membrane interaction in the cochlear outer hair cell wall". Euromech 344: Fluid-structure interactions in biomechanics (1996) (London, England)
    50. Ratnanather, J.T., A.A. Spector, A.S. Popel, and W.E. Brownell. "Membrane viscoelastic properties of dancing outer hair cells of the inner ear". Mathematics and Molecular Biology IV (1995) (Santa Fe, NM)
    51. Zhi, M., J.T. Ratnanather, and W.E. Brownell. "Triggering water permeability changes in outer hair cells". Midwinter Meeting of the Association for Research in Otolaryngology (1995) (St. Petersburg, FL)
    52. Popel, A.S., J.T. Ratnanather, P.S. Sit, and W.E. Brownell. "Micromechanics of the cochlear outer hair cell". 2nd World Congress in Biomechanics (1994) (Amsterdam, Holland)
    53. Sit, P.S., C.A. Bittner, J.T. Ratnanather, and W.E. Brownell. "Vesiculation of the outer hair cell cytoplasmic membrane". Midwinter Meeting of the Association for Research in Otolaryngology (1994) (St. Petersburg, FL)
    54. Ratnanather, J. T., W.E. Brownell, and A.S. Popel. "Mechanical properties and water permeability coefficient of the outer hair cell". Midwinter Meeting of the Association for Research in Otolaryngology (1993) (St. Petersburg, FL)
    55. Ratnanather, J.T., and P.G. Daniels. "Self—induced thermal boundary layer separation". 44th Annual meeting of the Division of Fluid Dynamics of the American Physical Society (1991) (Phoenix, AZ)
    56. Ratnanather, J.T., and P.G. Daniels. "On self--induced thermal boundary layer separation". 40th British Applied Mathematics Colloquium (1991) (Oxford, England)
    57. Ratnanather, J.T. "E-mail: a tool for the disabled scientist and student". “Changing lives: New technology for people with disabilities'” symposium at American Association for the Advancement of Science Annual Meeting (1991) (Washington DC)
    58. Ratnanather, J.T. "E-mail: - the way forward". XVIIth Int. Congress on the Education of the Deaf (1990) (Rochester, NY)
    59. Ratnanather, J.T., and W.R.C. Phillips. "The turbulence law of the wake in a boundary layer". 42nd Annual meeting of the Division of Fluid Dynamics of the American Physical Society (1989) (Palo Alto, CA)
    60. Ratnanather, J.T., and W.R.C. Phillips. "The outer region of a turbulent boundary layer". 41st Annual meeting of the Division of Fluid Dynamics of the American Physical Society (1988) (Buffalo, NY)

    Publications: Book Chapters

    1. Ratnanather, J.T., A.A. Spector, A.S. Popel, and W.E. Brownell. "Is the outer hair cell wall viscoelastic?." Diversity in Auditory Mechanics. World Scientific, 1997. (ISBN 9810227124)
    2. Brownell, W.E., J.T. Ratnanather, A.S. Popel, M. Zhi, and P.S. Sit. "Labyrinthine lateral walls: cochlear outer hair cell permeability and mechanics." Active Hearing. Elsevier Science Ltd, 1995. (ISBN 0080425143)
    3. Ratnanather, J.T., W.E. Brownell, and A.S. Popel. "The mechanical properties of the cochlear outer hair cell." Biophysics of Hair Cell Sensory Systems. World Scientific Press, 1993. (ISBN 9810215223)

    Publications: Journals

    1. Penumetcha, N., Jedynak, B., Hosakere, M., Ceyhan, E., Botteron, K.N., Ratnanather, J.T. . "Segmentation of arteries in MPRAGE images of the ventral medial prefrontal cortex ". Comp. Med. Imag. Graph (2008)
    2. Wang, L., Beg, M.F., Ratnanather, J.T., Ceritoglu, C., Younes, L., Morris, J.C., Csernansky, J.G., Miller, M.I. . "Large Deformation Diffeomorphism and Momentum Based Hippocampal". IEEE Trans Med Imaging (2007)
    3. Fawkes, W.G., Ratnanather, J.T.. "Music at Mary Hare Grammar School for the Deaf from 1975 to 1988: a historical perspective". Research Issues in Music Education (2007)
    4. Miller, M.I., Priebe, C., Qiu, A., Kolasny, A., Brown, T., Park, Y., Ratnanather, J.T., Busa, E., Jovicich. J., Yu, P., Dickerson, B., Buckner, R.L. and Morphometry BIRN. . "Collaborative Computational Anatomy: An MRI Morphometry Study of the Human Brain via Diffeomorphic Metric Mapping". Human Brain Mapping (2007)
    5. Zhang, S., Younes, L., Zweck, J., Ratnanather, J.T. . "Diffeomorphic Surface Flow: a novel method of surface evolution. ". SIAM J. App. Math. (2007)
    6. Qiu, A., Vaillant, M., Barta, P., Ratnanather, J.T., Miller, M.I. . "Surface-Based Gaussian Random Field Model with Application to Cortical Thickness Variation of Left Planum Temporale in Schizophrenia and Bipolar Disorder". Human Brain Mapping (2007)
    7. Qiu, A., Younes, L., Wang, L., Ratnanather, J.T., Gillespie, S.K., Kaplan, G., Csernansky, J.G. , Miller, M.I.. "Combining Anatomical Manifold Information via Diffeomorphic Metric Mappings for Studying Cortical Thinning of the Cingulate Gyrus in Schizophrenia". Neuroimage 37 (2007):821-833
    8. Wang, L., Hosakere, M., Trein, J.C.L., Ratnanather, J.T., Barch, D.M., Thompson, P.A., Qui, A., Gado, M., Miller, M.I., Csernansky, J.G. . "Abnormalities of Cingulate Gyrus Neuroantomy in Schizophrenia". Schizophrenia Res. 93 (2007):66-78
    9. Priebe, C.E., M.I. Miller, and J.T. Ratnanather. "Segmenting Magnetic Resonance Images via Hierarchical Mixture Modelling". Computational Statistics and Data Analysis 50. 2 (2006):551-567 (HTML/PDF)
    10. Spector, A.A , K. Grosh, J.T. Ratnanather, N. Deo, and R.M. Raphael. "Electromechanical models of the outer hair cell composite membrane.". Journal of Membrane Biology 209 (2006):1-18 (HTML/PDF)
    11. Zhi M., J.T. Ratnanather, A.S. Popel, and W.E. Brownell. "Hypotonic swelling of salicylate treated cochlear outer hair cells". Hearing Research 228. 1-2 (2006):95-104
    12. Hurdal, M.K., D.A. Lee, J.T. Ratnanather, T. Nishino, K.N. Botteron, and M.I. Miller. "Automated cortical analysis methods: from MRI data acquisition to quasi-conformal cortical flat maps with reference to medial prefrontal cortex". NeuroImage (2006)
    13. Wang, L., M. Hosakere, J.C.L. Trein, J.T. Ratnanather, D.M. Barch, P.A. Thompson, A. Qui, M. Gado, M.I. Miller and J.G. Csernansky. "Abnormalities of Cingulate Gyrus Neuroanatomy in Schizophrenia". Archives of General Psychiatry (2006)
    14. Munn, M.A., J. Alexopoulos, T. Nishino, C.M. Babb, L.A. Flake, T. Singer, J.T. Ratnanather, R.D. Todd, M.I. Miller, and K.N. Botteron. "Amygdala volume analysis in female twins with major depression". Biological Psychiatry (2006)
    15. Lal, R.M., C. Poynton, S. Mori, J.T. Ratnanather, and M.I. Miller. "Probabilistic Generation of White Matter Fiber Tracts in Diffusion Tensor Imaging". N/A (2006)
    16. Davis A.M.J., Ceritoglu, C. and J.T. Ratnanather. "A Stokesian analysis of a viscous jet impinging on a planar wall". N/A (2006)
    17. Zhang, S., Younes, L., Zweck, J., Ratnanather, J.T. "Diffeomorphic Surface Flow: a novel method of surface evolution". SIAM J. App. Math (2006)
    18. Ceyhan, E., Ceritoglu, C., Beg, M.F., Wang, L., Morris, J.C., Csernansky, J.G., Miller, M.I., Ratnanather, J.T. . "Metric distances between hippocampal shapes predict different rates of shape changes in dementia of Alzheimer type and nondemented subjects ". IEEE Trans Med Imag (2006)
    19. Younes, L., Zweck, J., Wang, L., Hosakere, M., Ratnanather, J.T., Csernansky, J.G., Miller, M.I. . "Statistical Analysis of Surface Roughness via Local Area Maps: Application to the Cingulate Gyrus in Healthy and Schizophrenic Subjects ". NeuroImage (2006)
    20. Ceyhan, E., Hosakere, M., Nishino, T., Alexopolous, J., Todd, R.D., Ratnanather, J.T., Miller, M.I., Botteron, K.N. . "Statistical Analysis of Labeled Cortical Distance Maps ". Statistica Sinica (2006)
    21. Ceyhan, E., Hosakere, M., Nishino, T., Alexopolous, J., Todd, R.D., Ratnanather, J.T., Miller, M.I., Botteron, K.N. . "Censoring Methods for Statistical Analysis of Labeled Cortical Distance Maps ". Statistica Sinica (2006)
    22. Ratnanather, J.T., L. Wang, M.B. Nebel, M. Hosakere, X. Han, J.G. Csernansky, and M.I. Miller. "Validation of semiautomated methods for quantifying cingulate cortical metrics in schizophrenia". Psychiatry Research: NeuroImaging 132 (2004):53-68 (HTML/PDF)
    23. Holm, D.D., J.T. Ratnanather, A. Trouvé, and L. Younes. "Soliton Dynamics in Computational Anatomy". NeuroImage 23 (2004):S170-S178 (HTML/PDF)
    24. Csernansky, J.G., L. Wang, S.C. Joshi, J.T. Ratnanather, and M.I. Miller. "Computational Anatomy and Neuropsychiatric Disease: Probabilistic Assessment of Variation and Statistical Inference of Group Difference, Hemispheric Asymmetry, and Time-Dependent Change". NeuroImage 23 (2004):S56-S68 (HTML/PDF)
    25. Miller, M.I., M. Hosakere, A.R. Barker, C.E. Priebe, N. Lee, J.T. Ratnanather, L. Wang, M. Gado, J.C. Morris, and J.G. Csernansky. "Labelled Cortical Mantle Distance Maps in the Cingulate Quantify Differences Between Dementia of the Alzheimer Type and Healthy Aging". Proceedings of the National Academy of Sciences 100. 25 (2003):15172-15177 (HTML/PDF)
    26. Ratnanather, J.T., N.A. Honeycutt, N.G. Lee, H.M. Morris, A.C. Dziorny, M.K. Hurdal, P.E. Barta, G.D. Pearlson, and M.I. Miller. "Dynamic Programming generation of boundaries of local coordinatize submanifolds in the neocortex: application to the Planum Temporale.". NeuroImage 20 (2003):359-377 (HTML/PDF)
    27. Ratnanather, J.T., K.N. Botteron, T. Nishino, R. Lal, A.B. Massie, S.G. Patel, S. Peddi, R.D. Todd, and M.I. Miller. "Validation of Cortical Analysis of the Medial Prefrontal Cortex". NeuroImage 14 (2001):1058-1069 (PDF)
    28. Daniels, P.G. and J.T. Ratnanather. "On the thermal field of a separating wall jet". Journal of Engineering Mathematics 41 (2001):372-382 (PDF)
    29. Miller, M.I., A. Massie, J.T. Ratnanather, K.N. Botteron, and J.G. Csernansky. "Bayesian construction of geometrically based cortical thickness metrics". NeuroImage 12 (2000):676-687 (PDF)
    30. Ratnanather, J.T., W.E. Brownell, and A.S. Popel. "Analysis of the hydraulic conductivity of the extracisternal space of the cochlear outer hair cell". Journal of Mathematical Biology 40 (2000):372-382 (PDF)
    31. Ratnanather, J.T., M. Zhi, W.E. Brownell, and A.S. Popel. "The ratio of elastic moduli of cochlear outer hair cell derived from osmotic experiments". Journal of Acoustical Society of America 99 (1996):1025-1028 (PDF)
    32. Ratnanather, J.T., M. Zhi, W.E. Brownell, and A.S. Popel. "Measurements and a model of the outer hair cell hydraulic conductivity". Hearing Research 96 (1996):33-40 (PDF)
    33. Ratnanather, J.T., and P.G. Daniels. "Solution of the thermal boundary layer equations in regions of flow reversal". SIAM Journal of Applied Mathematics 55 (1995):192-204 (PDF)
    34. Phillips, W.R.C., and J.T. Ratnanather. "The outer region of a turbulent boundary layer". Physics of Fluids A 2 (1990):427-434 (PDF)

    Publications: Conference Proceedings

    1. Lee, N., Penumetcha, N., Priebe, C.E., Ratnanather, J.T., Miller. M.I. . "Validation of Alternating Kernel Mixture Method Based Segmentation of the Human Brain". Proc. Frontiers in the Convergence of Bioscience and Information Technology, 2007. (2007)
    2. Ceyhan, E., Fong, L., Tasky, T.N., Hurdal, M.K., Beg, M.F., Martone, M.E., Ratnanather, J.T.. "Type-Specific Analysis of Morphometry of Dendrite Spines of Mice". 5th Int. Symp. Image Signal Proc. Analysis, ISPA 2007 (2007)
    3. Ceyhan, E., Hosakere, M., Nishino, T., Alexopolous, J., Todd, R.D., Ratnanather, J.T., Miller, M.I. . "Statistical Analysis of Morphometric Measures Based on Labeled Cortical Distance Maps". 5th Int. Symp. Image and Signal Processing and Analysis, ISPA 2007 (2007)
    4. Ceyhan, E., Ölken, R.Ç., Fong, L., Tasky, T.N., Hurdal, M.K., Beg, M.F., Martone, M.E., Ratnanather, J.T. . "Modeling Metric Distances of Dendrite Spines of Mice Based on Morphometric Measures". Int. Symp on Health Informatics and Bioinformatics, 2007. (2007)
    5. Ceyhan, E., Ölken, R.Ç., Fong, L., Tasky, T.N., Hurdal, M.K., Beg, M.F., Marton, M.E., Ratnanather, J.T. . "Modeling morphometric measures of dendrite spines of mice based on metric distances". HIBIT 2007 (2006)
    6. Ratnanather, J.T. "Computational Anatomy of the Auditory Cortex: implications for auditory rehabilitation". "From Cochlea to Cortex: understanding auditory dysfunction" Proceedings of the 4th Research Symposium for Non-Scientists at the International Convention of the Alexander Graham Bell Association for the Deaf and Hard of Heari (2004) (June 2004)
    7. Ratnanather, J.T, C.E. Priebe, and M.I. Miller. "Semi-automated segmentation of cortical subvolumes via hierarchical mixture modeling". Medical Imaging 2003: Image Processing. Proceedings of the SPIE, Edited by Sonka, M., and J.M. Fitzpatrick Vol 5032 (2003):1602-1612
    8. Winslow, R.L., P. Helm, W. Baumgartner, S. Peddi, J.T. Ratnanather, E. McViegh, and M.I. Miller. "Imaging-based integrative models of the heart: closing the loop between experiment and simulation". 'In Silico' Simulation of Biological Processes: Novartis Foundation Symposium, Edited by Bock, G., and J.A. Goode 247 (2002):129-143
    9. Popel, A.S., J.T. Ratnanather, A.A. Spector, P.S. Sit, R.A. Jerry, and W.E. Brownell. "Mechanics of the cochlear outer hair cell". Proceedings of the Fourth China-Japan-USA-Singapore Conference on Biomechanics (1995) (Taiyuan, Shaxi, China)
    10. Sit, P.S., J.T. Ratnanather, A.S. Popel, and W.E. Brownell. "Micromechanical properties of the outer hair cell of the inner ear". Proceedings of the 13th Southern Biomedical Engineering Conference (1994) (Washington, DC)
    11. Brownell, W.E., J.T. Ratnanather, P.A. Pollice, M. Zhi, and P.S. Sit. "Subsurface cisternal contributions to outer hair cell mechanics and electromotility". Proceedings of the Sendai Symposium 3 (1993):111-115 (Tohoku University School of Medicine, Sendai, Japan)
    12. Ratnanather, J.T., and J.S. Rollett. "A Petrov-Galerkin scheme for incompressible turbulent flows". Proceedings of the 6th International Conference on Finite Element Methods, Edited by Steven, G.P., D.W. Kelly, and C. McIvor (1991) (University of Sydney, Sydney, Australia)
    13. Ratnanather, J.T., and P.G. Daniels. "Reversed flow calculations of high Prandtl number thermal boundary layer separation". Proceedings of 4th International Symposium on Transport Phenomena in Heat and Mass Transfer (ISTP-IV). Elsevier Science Publishers, Edited by J.A. Reizes (1991) (Sydney, Australia)

    Publications: Other

    1. Raphael, R.M. and J.T. Ratnanather. "Deaf and Hard of Hearing People in Biomedical Engineering and Bioengineering". Volta Voices. March/April (2003):22-24
    2. Ratnanather, J.T. "The Power of Two Line Voice Carry Over". Contact 12 (1997):22-27
    3. Ratnanather, J.T. "Eight years in higher education: a deaf perspective". European Conference: A european university for students with special needs, Edited by Marco, C., (1990) (University of Mons, Belgium)
    4. Ratnanather, J.T. "International and national research computer networks - their implications for hearing impaired students". European Deaf Students Can …. : Deaf Students in Higher Education. Deaf-Fax, Edited by Carter, K., (1988) (University of Reading, England)
    5. Ratnanather, J.T. "Experiences of a deaf undergraduate". Proceedings of the XVIth International Congress on the Education of the Deaf. Croom-Helm Publishers, Edited by Taylor, I.G., (1987) (Manchester, UK)
    6. Ratnanather, J.T. "Studies in simple turbulence models". Oxford University Computing Laboratory Numerical Analysis Group Research Report (1987) (Monograph no. NA-87/7)

    Supervised Students

    • Michael An Graduated Undergraduate
    • Matthew Browne Graduated Undergraduate University of California, San Diego
    • Won Ho Cho Sophomore Undergraduate
    • Eric Cochran Graduated Undergraduate
    • Britni Crocker Sophomore Undergraduate
    • Lisa Fong Graduated Undergraduate Syracuse University
    • Russell Frisby Graduated Undergraduate
    • Rossitza Irobalieva Graduated Undergraduate University of Maryland Baltimore County
    • Ahra Joh Sophomore Undergraduate
    • Kate Johnson Graduated Undergraduate
    • Suraj Kabadi Senior Undergraduate
    • Ann Kennedy Junior Undergraduate
    • Monica Kim Sophomore Undergraduate
    • Neha Malhotra Senior Undergraduate
    • Neeraja Penumetcha Graduated Graduate
    • Dominic Pisano Graduated Undergraduate
    • Clare Poynton Graduated Undergraduate
    • Carolyn Purington Freshman Undergraduate
    • Andrey Rukhin Graduate
    • Yoshiaki Sono Sophomore Undergraduate
    • Stephen Tang Senior Undergraduate
    • Tiffany Tasky Graduated Undergraduate
    • Priyan Weerapulli Graduated Undergraduate Michigan State University
    • Sirong Zhang Postdoc

     
     




    301 Clark Hall
    3400 N. Charles Street
    Baltimore, MD 21218
    Office: (410) 516-3826
    Fax: (410)516-4594
    webmaster@cis.jhu.edu