Patrick Barta
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Patrick Barta

Associate Professor of Biomedical Engineering (Whiting School of Engineering, Johns Hopkins University)

Associate Professor of Psychiatry (Department of Psychiatry and Behavioral Sciences, Johns Hopkins Hospital)

Private Practice of Psychiatry

Biomedical Engineering

Telephone

(410) 337-8084 (Psychiatric Practice Phone)

(410) 516-4594 (Office Fax)

(410) 516-6722 (Office Phone)

World Wide Web

Home Page

Awards

  • Phi Beta Kappa
    1977
  • Tau Beta Pi
    1978

Education

  • MD Medicine, Johns Hopkins, 1978 - 1985
  • PhD Biomedical Engineering, Johns Hopkins, 1978 - 1985
  • BES Bioengineering, Johns Hopkins, 1974 - 1978

Experience

  • Associate Professor (Department of Psychiatry and Behavioral Sciences, The Johns Hopkins Hospital). 1993 - Present
  • Associate Professor (Department of Biomedical Engineering, The Johns Hopkins University). 2003 - Present
  • Psychiatrist (Private Practice, Towson, MD). 2003 - Present
  • Assistant Professor (Department of Psychiatry and Behavioral Sciences, The Johns Hopkins Hospital). 1989 - 1993
  • Residency in Psychiatry (Johns Hopkins). 1986 - 1989
  • Consultant (Operational and Clinical Systems, The Johns Hopkins Hospital). 1985 - 1988
  • Internship in Psychiatry (Johns Hopkins). 1985 - 1986

Professional Activities

  • American Psychiatric Association (1988 - Present)
  • Maryland Psychiatric Association (1988 - Present)
  • Johns Hopkins Medical and Surgical Society (1988 - Present)
  • Finance Committee, Department of Psychiatry (1994 - 1996)
  • Electronic Patient Record Committee (1995)
  • Medical School Admissions Committee (1989 - 1992)
  • Frequent ad hoc reviewer for several peer-revie committees including: Small Business Innovation Reserach grants, Brain Map, SSS-X Radiology and Veteran's administration grants (1989)

Research Interests

  • Stereology: Particularly interested in applying methods from stereology to the problem of measuring things in volume data. Written a program, Measure, for analyzing volume data using stereological techniques that is used by several groups at Hopkins and elsewhere.
  • Schizophrenia: Primary psychiatric interest is in the neuroanatomy of schizophrenia, particularly cortical manifestations.
  • MRI Data Processing: Interested in techniques to decrease RF field inhomogeneity, segmentation and warping.
  • Functional MRI: Top priority at present is writing a set of routines for processing functional MRI data.

Publications: Journals

  1. Qiu, A., B.J. Rosenau, A.S. Greenberg, M.K. Hurdal, P. Barta, S. Yantis, and M.I. Miller. "Estimating Linear Cortical Magnification in Human Primary Visual Cortex via Dynamic Programming". NeuroImage (2006)
  2. Strasser, H.C., J. Liyestorm, E.R. Ashby, N.A. Honeycutt, D.J. Schretlen, A.E. Pulver, R.O. Hopkins, J.R. Depaulo, J.B. Potash, B. Schweizer, K.O. Yates, E. Kurian, P.E. Barta, and G.D. Pearlson. "Hippocampal and Ventricular Volumes in Psychotic and Nonpsychotic Bipolar Patients Compared with Schizophrenia Patients and Community Control Subjects: A Pilot Study". Biological Psychiatry 57. 6 (2005):633-639
  3. Barta, P.E., M.I. Miller, and A. Qiu. "A Stochastic Model for the Laminar Structure of Cortex from MRI". IEEE Transaction in Medical Imaging 24. 6 (2005):728-742
  4. Buchanan, R.W., A. Francis, C. Arango, K. Miller, D.M. Lefkowitz, R.P. McMahon, P.E. Barta, G.D. Pearlson, and M.I. Miller. "Morphometric Assesment of the Heteromodal Association Cortex in Schizophrenia". American Journal of Psychiatry 161. 2 (2004):322-331
  5. Barta, P., and P. Dazzan. "Hemispheric Surface Are: Sex, Laterality and Age Effects". Cerbral Cortex 13. 4 (2003):364-370
  6. Ratnanather, J.T., P.E. Barta, N.A. Honeycutt, N. Lee, H.M. Morris, A.C. Dziorny, M.K. Hurdal, G.D. Pearlson, and M.I. Miller. "Dynamic Programming Generation of Boundaries of Local Coordinatized Submanifolds in the Neocortex: Application to the Planum Temporale". NeuroImage 20. 1 (2003):359-377
  7. Rivkin, P., M. Kraut, P. Barta, J. Anthony, A.M. Arria, and G. Pearlson. "White Matter Hyperintensity Volume in Late-onset and Early-onset Schizophrenia". International Journal of Geriatric Psychiatry 15. 12 (2000):1085-1089
  8. Aylward, E.H., A.M. Codori, A. Rosenblatt, M. Sherr, J. Brandt, O.C. Stine, P.E. Barta, G.D. Pearlson and C.A. Ross. "Rate of Caudate Atrophy in Presymptomatic and Symptomatic Stages of Huntington's Disease". Movement Disorder 15. 3 (2000):552-560
  9. Honeycutt, N.A., A. Musick, P.E. Barta, and G.D. Pearlson. "Measurement of the Planum Temporale (PT) on Magnetic Resonance Imaging Scans: Temporal PT Alone with Parietal Extension". Psychiatry Research 98. 2 (2000):103-116
  10. Frederikse, M., A. Lu, E. Aylward, P.E. Barta, T. Sharma and G. Pearlson. "Sex Differences in Inferior Parietal Lobule Volume in Schizophrenia". American Journal of Psychiatry 157. 3 (2000):422-427
  11. Schretlen, D., G.D. Pearlson, J.C. Anthony, E.H. Aylward, A.M. Augustine, A. Davis and P.E. Barta. "Elucidating the Contributions of Processing Speed, Executive Ability, and Frontal Lobe Volume to Normal Age-related Differences in Fluid Intelligence". Journal of International Neuropsychological Society 6. 1 (2000):52-61
  12. Aylward, E.H., N.J. Minshew, G. Goldstein, N.A. Honeycutt, A.M. Augustine, K.O. Yates, P.E. Barta and G.D. Pearlson. "MRI Volmes of Amygdala and Hippocampus in Non-mentally Retarded Autistic Adolescents and Adults". Neurology 53. 9 (1999):2145-2150
  13. Frederikse, M., A. Lu, E. Aylward, P.E. Barta, and G.D. Pearlson. "Sex Differences in Inferior Parietal Lobule". Cerbral Cortex 9. 8 (1999):896-901
  14. Sharma, T., E. Lancaster, T. Sigmundsson, S. Lewis, N. Takei, H. Gurling, P. Barta, G.D. Pearlson, and R. Murray. "Lack of Normal Pattern of Cerbral Asymmetry in Familial Schizophrenic Patients and Their Relatives -- The Maudlsey Family Study". Schizophrenia Research 40. 2 (1999):111-120
  15. Aylward, E.H., Q. Li, N.A. Honeycutt, A.C. Warren, M.B. Pulsifier, P.E. Barta, M.D. Chan, P.D. Smith, M. Jerram, and G.D. Pearlson. "MRI Volumes of the Hippocampus and Amygdala in Adults with Down's Syndrome with and without Dementia". American Journal of Psychiatry 156. 4 (1999):564-568
  16. Honeycutt, N.A., P.D. Smith, E.H. Aylward, Q. Li, M. Chan, P.E. Barta, M.D. Chan, P.D. Smith, M. Jerram, and G.D. Pearlson. "Mesial Temporal Lobe Measurements on Magnetic Resonance Imaging Scans". Psychiatry Research 83. 2 (1998):85-94
  17. Buchanan, R.W., K. Vladar, P.E. Barta, and G.D. Pearlson. "Structural Evaluation of the Prefrontal Cortex in Schizophrenia". American Journal of Psychiatry 155. 8 (1998):1049-1055
  18. Sharma, T., E. Lancaster, D. Lee, S. Lewis, T. Sigmundsson, N. Takei, H. Gurling, P.E. Barta, G.D. Pearlson, and R. Murray. "Brain CHanges in Scizophrenia. Volumetric MRI study of Families Multiply Affected with Schizophrenia -- The Maudsley Family Study 5". British Journal of Psychiatry 173 (1998):132-138
  19. Pearlson, G.D., S.N. Breiter, E.H. Aylward, A.C. Warren, M. Grygorcewicz, S. Frangou, P.E. Barta, and M.B. Pulsifier. "MRI Brain Changes in Subjects with Down Syndrome with and without Dementia". Developmental Medicine Child Neurology 40. 5 (1998):326-334
  20. Schlaepfer, T.E., E.C. Strain, B.D. Greenberg, K.L. Preston, E. Lancaster, G.E. Bigelow, P.E. Barta, and G.D. Pearlson. "Site of Opioid Action in the Human Brain: Mu and Kappa Aonists' Subjective and Cerebral Blood Flow Effects". American Journal of Psychiatry 155. 4 (1998):470-473
  21. Aylward, E.H., N.B. Anderson, F.W. Bylsma, M.V. Wagster, P.E. Barta, M. Sherr, J. Feeney, A. Davis, A. Rosenblatt, G.D. Pearlson, and C.A. Ross. "Frontal Lobe Volume in Patients with Huntington's Disease". Neurology 50. 1 (1998):252-258
  22. Frangou, S., E.H. Aylward, A. Warren, T. Sharma, P.E. Barta, and G.D. Pearlson. "Small Planum Temporale Volume in Down's Syndrome: A Volumetric MRI Study". American Journal of Psychiatry 154. 10 (1997):1424-1249
  23. Barta, P.E., L. Dhingra, R. Royall and E. Schwartz. "Improving Stereological Estimates for the Volume of Structures Identified in Three-Dimensional Arrays of Spatial Data". Journal of Neuroscience Methods 75. 2 (1997):111-118
  24. Aylward, E.H., A. Augustine, Q. Li, P.E. Barta, and G.D. Pearlson. "Measurement of Frontal Lobe Volume on Magentic Resonance Imaging Scans". Psychiatry Research 75. 1 (1997):23-30
  25. Aylward, E.H., Q. Li, Q.R. Habbak, A. Warren, M.B. Pulsifier, P.E. Barta, M. Jerram. and G.D. Pearlson. "Basal Ganglia Volume in Adults with Down Syndrome". Psychiatry Research 74. 2 (1997):73-82
  26. Barta, P.E., G.D. Pearlson, L.B. Brill 2nd, R. Royall, I.K. McGilchrist, A.E. Pulver, R.E. Powers, M.F. Casanova, A.Y. Tien, S. Frangou, and R.G. Petty. "Planum Temporale Asymmetry Reversal in Schizophrenia: Replication and Relationship to Gray Matter Abnormalities". American Journal of Psychiatry 154. 5 (1997):661-667
  27. Frangou, S., T. Sharma, T. Sigmudsson, P.E. Barta, G.D. Pearlson, and R.M. Murray. "The Maudsley Family Study 4. Normal Planum Temporale Asymmetry in Familial Schizophrenia. A Volumetric MRI Study". British Journal of Psychiatry 170 (1997):328-333
  28. Barta, P.E., R.E. Powers, E.H. Aylward, G.A. Chase, G.J. Harris, P.V. Rabins, L.E. Tune, and G.D. Pearlson. "Quantitative MRI Volume Changes in Late Onset Schizophrenia and Alzheimer's Disease Compared to Normal Controls". Psychiatry Research 68. 2-3 (1997):65-75
  29. Aylward, E.H., Q.R. Habbak, A.C. Warren, M.B. Pulsifier, P.E. Barta, M. Jerram. and G.D. Pearlson. "Cerebellar Volume in Adults with Down Syndrome". Archives of Neurology 54. 2 (1997):209-212
  30. Aylward, E.H., Q. Li, O.C. Stine, N. Ranen, M. Sherr, P.E. Barta, F.W. Bylsma, G.D. Pearlson and C.A. Ross. "Longitudinal Change in Basal Ganglia Volume in Patients with Huntington's Disease". Neurology 48. 2 (1997):394-399
  31. Pearlson, G.D., P.E. Barta, R.E. Powers, R.R. Menon, S.S. Richards, E.H. Aylward, E.B. Federman, G.A. Chase, R.G. Petty and A.Y. Tien. "Ziskind-Somerfeld Research Award 1996. Medial and Superior Temporal Gyral Volumes and Cerebral Asymmetry in Schizophrenia Versus Bipolar Disorder". Biological Psychiatry 41. 1 (1997):1-14
  32. Aylward, E.H., A.M. Codori, P.E. Barta, G.D. Pearlson G.J. Harris, and J. Brandt. "Basal Ganglia Volume and Proximity to Onset in Presymptomatic Huntington Disease". Archives of Neurology 53. 12 (1996):1293-1296
  33. Tune, L., P.E. Barta, D. Wong, R.E. Powers, G.D. Pearlson, A.Y. Tien, and H.N. Wagner. "Striatal Dopamine D2 Receptor Quantification and Superior Temporal Gyrus: Volume Detemination in 14 Chronic Schizophrenic Subjects". Psychiatry Research 67. 2 (1996):155-158
  34. Aylward, E.H., G.J. Harris, R. Hoehn-Saric, P.E. Barta, S.R. Machlin, and G.D. Pearlson. "Normal Caudate Nucleus in Obsessive-Compulsive Disorder Assessed by Quantitative Neuroimagin". Archives of General Psychiatry 53. 7 (1996):577-584
  35. Tien, A.Y., W.W. Eaton, T.E. Schlaepfer, I.K. McGilchrist, R. Menon, R. Powers, E.H. Aylward, P.E. Barta, M.E. Strauss, and G.D. Pearlson. "Exploratory Factor Analysis of MRI Brain Structure Measures in Schizophrenia". Schizophrenia Research 19. 2-3 (1996):93-101
  36. Harris, G.J., E.H. Aylward, C.E. Peyser, G.D. Pearlson, J. Brandt, J.V. Roberts-Twillie, P.E. Barta, and S.E. Folstein. "Single Photon emission Computed Tomographic Blood Flow and Magnetic Resonance Volume Imaging of Basal Ganglia in Huntington's Diesease". Archives of Neurology 53. 4 (1996):316-324
  37. Noga, J.T., E.H. Aylward, P.E. Barta, and G.D. Pearlson. "Cingulate Gyrus in Schizophrenic patients and Normal Volunteers". Psychiatry Research 61. 4 (1995):201-208
  38. Barta, P.E., R.G. Petty, I.K. McGilchrist, R.W. Lewis, M. Jerram, M.F. Casanova, R.E. Powers, L.B. Brill 2nd, and G.D. Pearlson,. "Asymmetry of the Planum Temporale: Methodological Considerations and Clinical Associations". Psychiatry Research 61. 3 (1995):137-150
  39. Menon, R.R., P.E. Barta, E.H. Aylward, S.S. Richards, D.D. Vaughn, A.Y. Tien, G.J. Harris, and G.D. Pearlson. "Posterior Superior Temporal Gyrus in Schizophrenia: Grey Matter Changes and Clinical Correlates". Schizophrenia Research 16. 2 (1995):127-135
  40. Aylward, E.H., P.D. Brettschneider, J.C. McArthur, G.J. harris, T.E. Schlaepfer, J.D. Henderer, P.E. Barta, A.Y. Tien, and G.D. Pearlson. "Magnetic Resonance Imaging Measurement of Gray Matter Volume Reductions in HIV Dementia". American Journal of Psychiatry 152. 7 (1995):987-994
  41. Petty, R.G., P.E. Barta, G.D. Pearlson, I.K. McGilchrist, R.W. Lewis, A.Y. Tien, A. Pulver, D.D. Vaughn, M.F. Casanova, and R.E. Powers. "Reversal of Asymmetry of the Planum Temporale in Schizophrenia". American Journal of Psychiatry 152. 5 (1995):715-721
  42. Aylward, E.H., A. Reiss, P.E. Barta, A. Tien, W. Han, J. Lee, and G.D. Pearlson. "Magnetic Resonance Imaging Measurement of Posterior Fossa Structures in Schizophrenia". American Journal of Psychiatry 151. 10 (1994):1448-1452
  43. Barta, P.E., S. Niziol, P. Le Guennec, and A. Pron. "Doping-induced Magnetic Phase Transition in Poly(3-Alkylthiophenes)". Physical Review B Condensed Matter 50. 5 (1994):3016-3024
  44. Schlaepfer, T.E., G.J. Harris, A.Y. Tien, L.W. Peng, S. Lee, E.B. Federman, G.A. Chase, P.E. Barta, and G.D. Pearlson. "Decreased Regional Cortical Gray Matter Volume in Schizophrenia". American Journal of Psychiatry 151. 6 (1994):842-848
  45. Aylward, E.H., J.V. Roberts-Twillie, P.E. Barta, A.J. Kumar, G.J. Harris, M. Geer, C.E. Peyser, and G.D. Pearlson. "Basal Ganglia Volumes and White Matter Hyperintensities in Patients with Bipolar Disorder". American Journal of Psychiatry 151. 5 (1994):687-693
  46. Aylward, E.H., J. Brandt, A.M. Codori, R.S. Magnus, P.E. Barta, and G.J. Harris. "Reduced Basal Ganglia Volume Associated with the Gene for Huntington's Disease in Asymptomatic at-risk Persons". Neurology 44. 5 (1994):823-828
  47. Harris, G.J., P.E. Barta, L.W. Peng, S. Lee, P.D. Brettschneider, A.Shah, J.D. Henderer, T.E. Schlaepfer, and G.D. Pearlson. "MR Volume Segmentation of Gray Matter and White Matter using Manual Thresholding: Dependence on Image Brightness". AJNR American Journal of Neuroradiology 43. 10 (1993):2099-2104
  48. Barta, P.E., S. Niziol, M. Zagorska, A. Pron, and Z. Trybula. "Magnetic Studies of FeCl4-doped Poly(3-Alkylthiophenes) and Poly(4,4'-dialkyl-2,2'bithiophenes)". Physical Review B Condensed Matter 48. 1 (1993):243-249
  49. Woodruff, P.W., G.D. Pearlson, M.J. Geer, P.E. Barta, and H.D. Chilcoat. "A Computerized Magnetic Resonance Imaging Study of Corpus Callosum Morphology in Schizophrenia". Psychological Medicine 23. 1 (1993):45-56
  50. Pearlson, G.D., L.E. Tune, D.F. Wong, E.H. Aylward, P.E. Barta, R.E. Powers, A.Y. Tien, G.A. Chase, G.J. Harris, and P.V. Rabins. "Quantitative D2 Dopamine Receptor PET and Structural MRI Changes in Late-onset Schizophrenia". Schizophrenia Bulletin 19. 4 (1993):783-795
  51. Schwartz, J.M., E.H. Aylward, P.E. Barta, L.E. Tune, and G.D. Pearlson. "Sylvian Fissure Size in Schizophrenia Measured with the Magnetic Resonance Imaging Rating Protocol of the Consortium to Establish a Registry for Alzheimer's Disease". American Journal of Psychiatry 149. 9 (1992):1195-1198
  52. Barta, P.E.. "Part II of the ABPN Certification Examination". American Journal of Psychiatry 149. 6 (1992):853 (Author Reply (854))
  53. Pearlson, G.D., G.J. Harris, R.E. Powers, P.E. Barta, E.E. Camargo, G.A. Chase, J.T. Noga, and L.E. Tune. "Quantitative changes in Mesial Temporal Volume, Regional Cerbral Blood Flow, and Cognition in Alzheimer's Disease". Archives of General Psychiatry 49. 5 (1992):402-408
  54. Piven, J., E. Nehme, J. Simon, P.E. Barta, G.D. Pearlson, and S.E. Folstein. "Magnetic Resonance Imaging in Autism: Measurement of the Cerebellum, Pons, and Fourth Ventricle". Biological Psychiatry 31. 5 (1992):491-504
  55. Harris, G.J., G.D. Pearlson, C.E. Peyser, E.H. Aylward, J. Roberts, P.E. Barta, G.A. Chase, and S.E. Folstein. "Putamen Volume Reduction on Magnetic Resonance Imaging Exceeds Caudate changes in Mild Huntington's Disease". Annals of Neurology 31. 1 (1992):69-75
  56. Barta, P.E., G.D. Pearlson, R.E. Powers, S.S. Richards, and L.E. Tune. "Auditory Hallucinations and Smaller Superior Temporal Gyral Volume in Schizophrenia". American Journal of Psychiatry 147. 11 (1990):1457-1462
  57. Miller, M.I., P.E. Barta, and M.B. Sachs. "Strategies for the Representation of a Tone in Background Noise in the Temporal Aspects of the Discharge Patterns of Auditry-nerve Fibers". Journal of Acoustical Society of America 81. 3 (1987):665-679
  58. Young, E.D., and P.E. Barta. "Rate Responses of Auditory Nerve Fibers to Tones in Noise Near Masked Threshold". Journal of Acoustical Society of America 79. 2 (1986):426-442

Supervised Students

  • L. Amodei Postdoc
  • Faisal Beg Graduate
  • Paola Dazzan Postdoc
  • Sophia Frangou Postdoc
  • M. Frederikse Postdoc
  • Nancy Honeycutt Postdoc
  • R. Kanaan Postdoc
  • Jin-Sun Kim Postdoc
  • Anqi Qiu Graduate
  • Sarah Reading Postdoc
  • Paul Rivkin Postdoc
  • T. Schlaepfer Postdoc
  • Tonmog Sharma Postdoc
 
 




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