Timothy J. A. Brown
Center for Imaging Science : About | Research | Publications | Education | Downloads

Timothy J. A. Brown, P.E.

Center for Imaging Science

Plan Ahead

  • Implement software tools to capture neuroimaging metadata to support study of disease
  • Implement shape analysis pipelines utilizing web services and supercomputers (including XSEDE)
  • Deliver computational anatomy tools to neuroimaging community to support study of shape change of subcortical structures
  • Use computational anatomy software to identify neuroimaging biomarkers associated with cognitive impairment and dementia
  • Improve methods to delineate subcortical structures in MRI

Employment

  • Johns Hopkins University - Center for Imaging Science, Senior Data Manager/Software Engineer. July, 2004 - present
  • UPS Logistics Technologies - Software Developer. June, 2000 - June, 2004
  • ADS Environmental Services, Inc. - Project Engineer. July 01, 1998 - June, 2000
  • Oakland County Drain Commisioner - Civil Engineer. November, 1990 - June 1998

Research Interests

  • Using Computational Methods to Define Anatomical Regions in the Brain.
  • Utilize High Performance Computing to solve large scale computationally intensive problems
  • Neurodegenerative Diseases including Alzheimer's Disease, Mild Cognitive Impairment, Huntingtons Disease
  • Software Development to deliver Computational Anatomy Tools to Users
  • Neuroanatomical structures: amygdala, caudate, entorhinal cortex, globus pallidus, hippocampus, putamen, thalamus.

Education

  • MS Computer ScienceJohns Hopkins University, 2003
  • BEng Civil EngineeringUniversity Of Surrey, England, 1990

Licensure

  • Licensed Professional Engineer - Michigan, Maryland

Projects

  • BIOCARD-SE Biomarkers of Cognitive Decline Among Normal Individuals: The BIOCARD Cohort Study.
  • PREDICT-HD An Observational Study of the Earliest Signs of Huntington Disease.

Publications:

  1. Wu, D., Faria, A., Younes, L., Mori, S., Brown, T., Johnson, H., Paulsen, J., Ross, C., Miller, M., Mapping the order and pattern of brain structural MRI changes using change-point analysis in premanifest Huntington's disease, Human Brain Mapping, 2017. Jun. 28
  2. Pettigrew, C., Soldan, A., Xhu, Y., Wang, M., Brown, T., Miller, M., Albert, M., Cognitive reserve and cortical thickness in preclinical Alzheimer's Disease, Brian Imaging and Behavior, 2017. Apr. 1
  3. Mori, S., Kageyama, Y., Hou, Z., Aggarwal, M., Patel, J., Brown, T., Miller, M., Wu, D., Troncoso, J., Elucidation of White matter tracts of the human amygdala through a detailed comparison between high-resolution postmortem MRI and histology, Frontiers in Neuroanatomy, 2017. Mar. 14
  4. Pettigrew, C., Soldan, A.,Zhu, Y., Wang, M., Moghekar, A., Brown, T., Miller, M., Albert, M., Cortical Thickness in Relation to Clinical Symptom Onset in Preclinical AD, NeuroImage Clinical, 2016. Jun. 15
  5. Faria, A. V., Ratnanather, J.T, Tward, D.J., Lee, D., van den Noort, F., Wu, D., Brown, T., Johnson, H., Paulsen, J.S., Ross, C.A., Younes, L., Miller, M.I., Linking white matter and deep gray matter alterations in premanifest Huntington Disease, NeuroImage Clinical, 2016. Feb. 26
  6. Wu, D., Ceritoglu, C., Li, Y., Chotiyanonta, J., Hou, Z., Hsu, J., Xu, X., Brown, T., Miller, M., Mori, S., Resource Atlases for Mutli-atlas Brain Segmentations with Mutliple Ontology Levels based on T1-weighted MRI, NeuroImage, 2016. Jan. 15
  7. Miller, M.I., Ratnanather, J.T., Tward, D., Brown, T., Lee, D., Ketcha, M., Mori, K., Wang, M.C., Mori, S., Albert, M., Younes, L. and BIOCARD Research Team, Network nuerodegeneration in Alzheimer's disease via MRI based shape diffeomorphometry and high-field atlasing, Front. Bioeng. Biotechnol. 3:54, doi: 10.3389/fbioe.2015.00054., April, 2015
  8. Soldan, A., Pettigrew, C., Lu, Y., Wang, M., Selnes, O., Albert, M., Brown, T., Ratnanather, J.T., Younes, Y., Miller, M., BIOCARD Research Team, Relationship of medial temporal lobe atrophy, APOE genotype, and cognitive reserve in preclinical Alzheimer's disease, Human Brain Mapping, April 2015.
  9. Miller, M.I., Younes, L., Ratnanather, J.T., Brown, T., Trinh, H., Lee, D.S., Tward, D., Mahon, P., Mori, S., Albert, M., the BIOCARD Research Team, Amygdalar Atrophy in Symptomatic AD Based on Diffeomorphometry: The BIOCARD Cohort, Neurobiology of Aging (2014), doi: 10.1016/j.neurobiolaging.2014.06.032.
  10. Miller, M.I., Younes, L., Ratnanather, J.T., Brown, T., Trinh, H., Postell, E., Lee, D., Wang, M.C., Mori, S., O'Brien, R., Albert, M., BIOCARD Research Team (2013). The Diffeomorphometry of Temporal Lobe Structures in Preclinical Alzheimer's Disease, NeuroImage: Clin. 3, 352-360. doi:10.1016/j.nicl.2013.09.001
  11. Ceritoglu, C., Tang, X., Chow, M., Hadjiabadi, D., Shah D., Brown, T., Burhanullah, M.H., Trinh, H., Hsu, J.T., Ament, K.A., Crocetti, D., Mori, S., Mostofsky, S.H., Yantis, S., Miller, M.I., Ratnanather, J.T., Computational analysis of LDDMM for brain mapping, Frontiers in Neuroscience, 2013 Aug 27
  12. Miller, M.I., Younes, L., Ratnanather, J.T., Brown, T., Wang, M.C., Lu, Y., Li, S., Pettigrew, C., Mori, S., Albert, M., Medial temporal lobe changes preceding symptom onset of mild cognitive impairment: The BIOCARD Cohort, Alzheimer's & Dementia., July 2013
  13. Younes, L., Ratnanather, J.T, Brown, T., Aylward, E., Nopoulos, P., Johnson, H., Magnotta, V.A., Paulsen, J.S., Margolis, R.L., Albin, R.L., Miller, M.I., Ross, C.A.,and the PREDICT-HD Investigators and Coordinators of the Huntington Study Group , Regionally selective atrophy of subcortical structures in prodromal HD as revealed by statistical shape analysis, Human Brain Mapp., 2012 Dec 20 doi: 10.1002/hbm.22214. [Epub ahead of print]
  14. Mielke, M.M., Okonkwo, O.C., Oishi, K., Mori, S., Tighe, S., Miller, M.I., Ceritoglu, C., Brown, T., Albert, M., Lyketsos, C.G. , Fornix integrity and hippocampal volume predict memory decline and progression to Alzheimer's disease, Alzheimer's & Dementia. 2012 Mar;8(2):105-113
  15. Mielke, M.M., Haughey, N., Bandaru, V.V.R., Schech, S., Carrick, R., Carlson, M.C., Mori, S.,Miller, M.I., Ceritoglu, C., Brown, T., Albert, M., Lyketsos, C.G. , Plasma ceramides are altered in MCI and predict cognitive decline and hippocampal volume loss, Alzheimer's & Dementia. 2010 Sep;6(5):378-85
  16. Qiu A, Brown T, Fischl B, Ma J, Miller M., Atlas Generation for Subcortical and Ventricular Structures with its Applications in Shape Analysis, IEEE Trans Image Process. 2010 Feb 2
  17. Miller MI, Priebe CE, Qiu A, Fischl B, Kolasny A, Brown T, Park Y, Ratnanather JT, Busa E, Jovicich J, Yu P, Dickerson BC, Buckner RL; Morphometry BIRN. Collaborative computational anatomy: an MRI morphometry study of the human brain via diffeomorphic metric mapping., Hum Brain Mapp. 2009 Jul;30(7):2132-41

Publications: Conference Proceedings

  1. Tward, D., Sicat, C., Brown, T., Bakker, A., Miller, M. Reducing Variability in Anatomical Definitions Over Time Using Longitudinal Diffeomorphic Mapping. International Workshop on Spectral and Shape Analysis in Medical Imaging, P 51-62, 2016
  2. J Ratnanather, T Brown, H Trinh, L Younes, MI Miller, S Mori, M Albert Shape analysis of hippocampus and amygdala in BIOCARD. Alzheimer's & Dementia 8 (4), P63, 2012
  3. Younes L, Ratnanather JT, Brown T, Albin R, Aylward E, Nopoulos P, Pierson, R, Johnson H, Magnotta V, Paulsen J, Margolis R, Miller MI, Ross CA Statistical shape analysis of atrophy of subcortical structures in prodromal Huntington's Disease. Human Brain Mapping, Quebec City, Canada, 2011
  4. Winslow R, Saltz J, Foster I, Carr JJ, Ge Y, Miller M, Younes L, Geman D, Granite S, Kurc T, Post A, Madduri R, Ratnanather T, Larkin J, Ardekani S, Brown T, Kolasny A, Reynolds K, Shipway M. The CardioVascular Research Grid (CVRG) Project. In: 2011 AMIA Summit on Translational Bioinformatics. March 7-9, San Francisco CA, : 2011. p. 77--81.
  5. Joseph Hennessey, Michael Bowers, Anthony Kolasny, Timothy Brown, Tilak Ratnanather and Michael Miller. "Computational Anatomy Works: Enhancing Paraview for Medical Imaging". TeraGrid Conference 2009 (pdf) (2009)
  6. Anqi Qiu, Timothy Brown, Bruce Fischl, Anthony Kolasny, Jun Ma, Randy L. Buckner, Michael I. Miller. "Subcortical Structure Template Generation with its Applications in Shape Analysis". Human Brain Mapping (2008)
  7. Aldridge, G.M., J.T. Ratnanather, M.E. Martone, M. Terada, M.F. Beg, L. Fong, E. Ceyhan, A.E. Kolasny, T.J.A. Brown, E.L. Cochran, S.J. Tang, D.V. Pisano, M. Vaillant, M.K. Hurdal, J.D. Churchill, W.T. Greenough, M.I. Miller, M.H. Ellisman. "Semiautomated shape analysis of dendrite spines from animal models of fragilex and parkinson's disease using large deformation diffeomorphic metric mapping". Society for Neuroscience, 35th Annual Meeting (2005) (pdf)
  8. Beg, M. F., Randy Buckner, Bruce Fischl, Youngser Park, Elvan Ceyhan, Carey Priebe, Can Ceritoglu, Anthony Kolasny, Timothy Brown, Brian Quinn, Peng Yu, Brian Gold, J. Tilak Ratnanather, Michael Miller. "BIRN Brain Morphometry. Pattern classification of hippocampal shape analysis in a study of Alzheimer's Disease". Human Brain Mapping, 11th Annual Meeting (2005) (pdf)



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