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| PI Name: | JOHN G. CSERNANSKY, M.D. | |||
| DEPARTMENT OF PSYCHIATRY WASHINGTON UNIVERSITY, SCHOOL OF MEDICINE ST. LOUIS, MO | ||||
| Project Title: | NEUROMORPHOMETRY IN SCHIZOPHRENIA | |||
Abstract:
Precisely defining the characteristics of neuroanatomical abnormalities in schizophrenia (i.e., volume losses, shape deformations and altered asymmetries) can provide critical evidence for determining the pathogenesis of schizophrenia. More
recently, there has been substantial interest in determining whether such neuroanatomical abnormalities show progressive changes over time. However, improved methodologies for neuromorphometiy are needed for such experiments. During the first funding period of this
project, we made further substantial progress in the development of high dimensional brain mapping (HDBM). In this renewal application, we show that HDBM can be used to measure brain structure
volumes, shapes and asymmetries with excellent reliability, and that HDBM can be used to detect abnormalities of the hippocampus and cingulate gyrus that discriminate matched groups of
schizophrenia and control subjects.
References:
Miller
MI, Massie A, Ratnanather, Botteron KN, and Csernansky JC:
Bayesian construction of geometrically based cortical thickness
metrics. NeuroImage. 12:676-687, 2000.
Links:
Conte Center, Washington University School of Medicine
Brain Subvolume Image Data for Validation of Segmentation
10 subvolumes are available in two formats: ANALYZE (7.5) and MATLAB formats.
Analyze should be able to read in the data irrespective of computer platform. The MATLAB data was generated on Linux but can be read in by other *IX systems.
Explanation of MATLAB format
- mrinz - nonzero mri intensity voxel
- mannz - corresponding hand segmented voxel
- coord - voxel coordinate identifier
- ic - x coordinate: if ic value is zero set to xdim
- jc - y coordinate: if jc value is zero set to ydim
- kc - z coordinate: if kc value is zero set to zdim
- xdim, ydim, zdim - voxel resolution
Hand segmentation labels
- CSF = 1
- GMA = 3
- WMA = 4
This data is available with registered usernames and passwords. If you have already registered, and your registration has been confirmed, you may proceed to the download page.
Supported by
- NIH R01-MH56584
- NIH R01-MH60883
- NIH P20-MH62130
- NIH P41-RR15241
- NSF NPACI